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1 of 25
Q.1 Which of the following statements is the most appropriate for sickle cell anaemia ?
- It cannot be treated with iron supplements.
- It is a molecular disease.
- It conferes resistance to acquiring malaria
- All of the above.
2 of 25
Q.2 The first genetic material could be
- protein
- cabohydrates
- DNA
- RNA
3 of 25
Q.3 The human chromosome with the highest and least number of genes in them are respectively
- chromosome 21 and Y
- chromosome 1 and X
- chromosome 1 and Y
- chromosome X and Y
4 of 25
Q.4 Who amongst the following scientist had no contribution in the development of the double helix model for the structure of DN A ?
- Rosalind Franklin
- Maurice Wilkins
- Erwin Chargaff
- Meselson and Stahl
5 of 25
Q.5 Which of the following steps in transcription is catalysed by RNA polymerase ?
- Initiation
- Elongation
- Termination
- All of the above
6 of 25
Q.6 Control of gene expression takes place at the level of
- DNA-replication
- transcription
- translation
- none of the above
7 of 25
Q.7 Which was the last human chromosome to be completely sequenced ?
- Chromosome 1
- Chromosome 11
- Chromosome 21
- Chromosome X
8 of 25
Q.8 In some viruses, DNA is synthesised by using RNA as template. Such a DNA is called
- A – DNA
- B – DNA
- cDNA
- rDNA
9 of 25
Q.9 If the sequence of initrogen bases of the coding strand of DNA in a transcription unit is: 5’ – ATGAATG – 3’, the sequence of bases in its RNA transcript would be
- 5’ – AUG A AUG – 3’
- 5’ – UACUU AC – 3’
- 5’ – CAUUCAU – 3’
- 5’ – GUAAGUA – 3’.
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Q.10 The RNA polymerase holocnzyme transcribes
- the promoter, structural gene and the terminator region
- the promoter and the terminator region
- the structural gene and the terminator region
- the structural gene only.
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Q.11 If the base sequence of a codon in mRNA is 5’ – AUG – 3′ the sequence of tRNA pairing with it must be
- 5’ – UAC – 3’
- 5’ – CAU – 3’
- 5’-AUG – 3’
- 5’ – GUA – 3’
12 of 25
Q.12 The amino acid attaches to the tRNA at its
- 5’- end
- 3’ – end
- anticodon site
- DHUloop.
13 of 25
Q.13 To initiate translation, the wiRNA first bind to
- the smaller ribosomal sub-unit
- the larger ribosomal sub-unit
- the whole ribosome
- no such specificity exists
14 of 25
Q.14 In E. colt, the lac operon gets switched on when
- lactose is present and it binds to the repressor
- repressor binds to operator
- RNA polymerase binds to the operator
- lactose is present and it binds to RNA polymerase.
15 of 25
Q.15 In DNA strand, the nucleotides are linked together by
- glycosidic bonds
- phosphodiester bonds
- peptide bonds
- hydrogen bonds
16 of 25
Q.16 If a double stranded DNA has 20% of cytosine, what will be the percentage of adenine in it ?
- 20%
- 40%
- 30%
- 60%
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Q.17 If the sequence of bases in one strand of DNA is ATGCATGCA, what would be the sequence of bases on complementary strand ?
- ATGCATGCA
- AUGCAUGCA
- TACTACGT
- UACGUACGU
18 of 25
Q.18 How far is each base pair from the next one in DNA double helix model ?
- 2 nm
- 3.4 nm
- 34 nm
- 0.34 nm
19 of 25
Q.19 Synthesis of DNA from RNA is explained by
- central dogma reverse
- reverse transcription
- feminism
- all of these
20 of 25
Q.20 Histone proteins are
- basic, negatively charged
- basic, positively charged
- acidic, positively charged
- acidic, negatively charged
21 of 25
Q.21 The structure in chromatin seen as ‘beads-on string’ when viewed under electron microscope are called
- nucleotides
- nucleosides
- histone octamer
- nucleosomes
22 of 25
Q.22 Find out the wrong statement about heterochromatin,
- It is densely packed
- It stains dark
- It is transcriptionally active.
- It is late replicating
23 of 25
Q.23 They year 2003 was celebrated as the 50th anniversary of discovery of
- transposons by Barbare Me Clintock
- structure of DNA by Watson and Crick
- Mendel’s laws of inheritance
- biotechnology by Kary Muliis.
24 of 25
Q.24 Amino acids which are specified by single codons are
- phenylalanine and arginine
- tryptophan and methionine
- valine and proline
- methionine and aroinine
25 of 25
Q.25 Which out of the following statements is incorrect ?
- Genetic code is ambiguous.
- Genetic code is deqenerate
- Genetic code is universal
- Genetic code is non-overlanning.
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