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Pharmacology
Pharmacology is the branch of medical science which deals with the mechanism, functioning, experimental analysis of impact of different drugs on living system.
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Lessons/Tutorials All ❱
30 Nov -0001
histamine and antihistamine drugs...
Notes All ❱
solotutes
12 Jun 2020
Some of drugs or chemicals are fatal to embryo development. Those drugs and chemical substances which produce deviations and abnormalities in the ...
prakash joshi
5 Nov 2020
There are some common drugs used in gynecology. Here is the list of drugs starting from "m" commonly used in obstetrics and gynecological conditio...
pharmacy exams
19 May 2021
Classification of antimicrobials is based on their type of action on microbes kill or reduce the number, spectrum of activity i.e can work on specif...
12 Jul 2021
Antihistamines are drugs which treat rhinitis and other allergies. Typically people take antihistamines as a cheap , generic, over-the-counter medicin...
12 Jul 2021
Antihistamines are drugs which treat rhinitis and other allergies. Typically people take antihistamines as a cheap , generic, over-the-counter medicin...
One Liners All ❱
Practice (MCQs) All ❱
1 of 36
Q.1 Compared to subcutaneous injection, the intramus- cular injection of drugs:
- Is more painful
- Produces faster response
- Is unsuitable for depot preparations
- Carries greater risk of anaphylactic reaction
Answer ✔ (b) Produces faster response
B. Pharma • Pharmacology • D. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
2 of 36
Q.2 The majority of drugs cross biological membranes primarily by
- Passive diffusion
- Facilitated diffusion
- Active transport
- Pinocytosis
Answer ✔ (a) Passive diffusion
B. Pharma • Pharmacology • D. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
3 of 36
Directions:
Q.3 Which of the following drugs is most likely to be absorbed from the stomach
- Hyoscine hydrobromide
- Morphine sulfate
- Diclofenac sodium
- Quinine dihydrochloride
Answer ✔ (c) Diclofenac sodium
B. Pharma • Pharmacology • D. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
4 of 36
Directions:
Q.4 The most important factor governing absorption of a drug from intact skin is
- Nature of the base used in the formulation
- Lipid solubility of the drug
- Molecular weight of the drug
- Site of application
Answer ✔ (b) Lipid solubility of the drug
B. Pharma • Pharmacology • D. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
5 of 36
Q.5 Bioavailability differences among oral formulations of a drug are most likely to occur if the drug
- Undergoes little first-pass metabolism
- Is incompletely absorbed
- Is freely water soluble
- Is completely absorbed
Answer ✔ (b) Is incompletely absorbed
B. Pharma • Pharmacology • D. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
6 of 36
Q.6 Marked redistribution is a feature of
- Highly plasma protein bound drugs
- Depot preparations
- Highly lipid soluble drugs
- Poorly lipid soluble drugs
Answer ✔ (c) Highly lipid soluble drugs
B. Pharma • Pharmacology • D. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
7 of 36
Q.7 High plasma protein binding
- Increases volume of distribution of the drug
- Generally makes the drug long acting
- Facilitates glomerular filtration of the drug
- Minimises drug interactions
Answer ✔ (b) Generally makes the drug long acting
B. Pharma • Pharmacology • D. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
8 of 36
Q.8 Which of the following is a prodrug
- Enalapril
- Menapril
- Thiazine
- Penicillin
Answer ✔ (a) Enalapril
B. Pharma • Pharmacology • D. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
9 of 36
Q.9 Microsomal enzyme induction can be a cause of
- Tolerance
- Physical dependence
- Psychological dependence
- Idiosyncrasy
Answer ✔ (a) Tolerance
B. Pharma • Pharmacology • D. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
10 of 36
Q.10 Glomerular filtration of a drug is affected by its
- Plasma protein binding
- Lipid solubility
- Degree of ionization
- Rate of tubular secretion
Answer ✔ (a) Plasma protein binding
B. Pharma • Pharmacology • D. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
11 of 36
Directions:
Q.1 Which of the following organs is innervated only by parasympathetic nerves
- Sweat glands
- Ciliary muscle
- Iris muscles
- Splenic capsule
Answer ✔ (b) Ciliary muscle
D. Pharma • Pharmacology • B. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
12 of 36
Directions: .
Q.2 The following cotransmitter is most probably involved in mediating nonadrenergic-noncholinergic (NANC) relaxation of the gut
- Nitric oxide (NO)
- Adenosine
- Neuropeptide Y (NPY)
- Kallidin
Answer ✔ (d) Kallidin
D. Pharma • Pharmacology • B. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
13 of 36
Q.3 The major postjunctional cholinergic receptor is of the muscarinic type at the following site
- Neuromuscular junction
- Postganglionic parasympathetic
- Adrenal medulla
- Autonomic ganglia
Answer ✔ (b) Postganglionic parasympathetic
D. Pharma • Pharmacology • B. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
14 of 36
Q.4 The choline ester resistant to both true and pseudo- cholinesterase is
- Bethanechol
- Butyrylcholine
- Methacholine
- Benzoylcholine
Answer ✔ (a) Bethanechol
D. Pharma • Pharmacology • B. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
15 of 36
Q.5 The smooth muscle structure that is relaxed by choli- nergic drugs is
- Colon
- Gastric fundus
- Bladder trigone
- Major bronchi
Answer ✔ (c) Bladder trigone
D. Pharma • Pharmacology • B. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
16 of 36
Q.6 Pilocarpine is used for
- Glaucoma
- Paralytic ileus
- Urinary retention
- Infection
Answer ✔ (a) Glaucoma
D. Pharma • Pharmacology • B. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
17 of 36
Q.7 The following inhibitor binds only to the ani-onic site of the cholinesterase enzyme
- Neostigmine
- Edrophonium
- Physostigmine
- Dyflos
Answer ✔ (b) Edrophonium
D. Pharma • Pharmacology • B. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
18 of 36
Q.8 Reactivation of cholinesterase enzyme occurs on hydrolysis of the inhibitor by the same enzyme mole- cule in case of the following anticholinesterase
- Edrophonium
- Dyflos
- Tacrine
- Neostigmine
Answer ✔ (d) Neostigmine
D. Pharma • Pharmacology • B. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
19 of 36
Q.9 Pyridostigmine differs from neostigmine in that
- It produces less muscarinic side effects
- It is more potent orally
- It is longer acting
- It does not have any direct action on NM receptor
Answer ✔ (c) It is longer acting
D. Pharma • Pharmacology • B. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
20 of 36
Q.10 The site of action of miotics for therapeutic effect in angle closure glaucoma is
- Canal of Schlemm
- Ciliary body
- Ciliary muscle
- Sphincter pupillae muscle
Answer ✔ (d) Sphincter pupillae muscle
D. Pharma • Pharmacology • B. Pharma • Bachelor of Pharmacy • Diploma in Pharmacy
21 of 36
Q.1 Labetalol differs from propranolol in that
- It has additional α1 blocking property
- It is a selective βS1 blocker
- It does not undergo first pass metabolism
- All of the above
Answer ✔ (a) It has additional α1 blocking property
D. Pharma • Pharmacology • Pharmacology • B. Pharma • Pharmacology • Post Graduation • Diploma in Pharmacy
22 of 36
Q.2 Select the β-adrenergic blocker that has additional β1blocking, vasodilator and antioxidant properties
- Celiprolol
- Metoprolol
- Carvedilol
- Acebutolol
Answer ✔ (c) Carvedilol
D. Pharma • Pharmacology • Pharmacology • B. Pharma • Pharmacology • Post Graduation • Diploma in Pharmacy
23 of 36
Q.3 Select the β adrenergic blocker that is primarily eliminated unchanged by renal excretion
- Atenolol
- Carbinol
- Ethanol
- Dompirol
Answer ✔ (a) Atenolol
D. Pharma • Pharmacology • Pharmacology • B. Pharma • Pharmacology • Post Graduation • Diploma in Pharmacy
24 of 36
Q.4 Select the ultrashort acting cardioselective β adre- nergic blocker
- Carbinol
- Ethanol
- Esmolol
- Propalol
Answer ✔ (c) Esmolol
D. Pharma • Pharmacology • Pharmacology • B. Pharma • Pharmacology • Post Graduation • Diploma in Pharmacy
25 of 36
Q.5 The following disease is worsened by propranolol
- Raynaud’s disease
- Infection
- Heart attack
- Epilepsy
Answer ✔ (a) Raynaud’s disease
D. Pharma • Pharmacology • Pharmacology • B. Pharma • Pharmacology • Post Graduation • Diploma in Pharmacy
26 of 36
Q.6 Select the drug which is administered orally for erectile dysfunction in men
- Albendazole
- Mebendazole
- Cocaine
- Sildenafil
Answer ✔ (d) Sildenafil
D. Pharma • Pharmacology • Pharmacology • B. Pharma • Pharmacology • Post Graduation • Diploma in Pharmacy
27 of 36
Q.7 Which of the following is a selective α1A receptor bloc- ker that affords symptomatic relief in benign prostatic hypertrophy without producing significant fall in blood pressure
- Doxazosin
- Alprostadil
- Tamsulosin
- Yohimbine
Answer ✔ (c) Tamsulosin
D. Pharma • Pharmacology • Pharmacology • B. Pharma • Pharmacology • Post Graduation • Diploma in Pharmacy
28 of 36
Q.8 The bladder trigone and prostatic muscles are relaxed by
- Adrenergic α1 agonists
- Adrenergic α1 antagonists
- Adrenergic α2 antagonists
- Adrenergic α2 agonists
Answer ✔ (b) Adrenergic α1 antagonists
D. Pharma • Pharmacology • Pharmacology • B. Pharma • Pharmacology • Post Graduation • Diploma in Pharmacy
29 of 36
Q.9 The drug which produces vasoconstriction despite being an α adrenergic blocker is
- Tolazoline
- Desmopressin
- Ergotamine
- Sildenafil
Answer ✔ (c) Ergotamine
D. Pharma • Pharmacology • Pharmacology • B. Pharma • Pharmacology • Post Graduation • Diploma in Pharmacy
30 of 36
Q.10 While undergoing a surgical procedure a patient deve- lops hypotension. Which drug can be injected intramuscularly to raise his BP
- Noradrenaline
- Mephentermine
- Isoxsuprine
- Oxymetazoline
Answer ✔ (b) Mephentermine
D. Pharma • Pharmacology • Pharmacology • B. Pharma • Pharmacology • Post Graduation • Diploma in Pharmacy
31 of 36
Q.1
- Weak acids
- Strong acids
- Weak Bases
- None of the above
Answer ✔ (a) Weak acids
Explanation:
B. Pharma • Pharmacology • Bachelor of Pharmacy
32 of 36
Q.2 A good example of chemical antagonism
- Heparin & Protamine
- Protamine & Zinc
- Heparin & Prothrombin
- All the above
Answer ✔ (a) Heparin & Protamine
Explanation: Chemical antagonism does not involve any receptors. Protamine is a positively charged protein at physiological pH and thus antagonizes the effects of Heparin which is negatively charged at physiological pH.
B. Pharma • Pharmacology • Bachelor of Pharmacy
33 of 36
Q.3 Active transport differs from facilitated transport in following ways, except
- Carrier is involved
- It is against concentration gradient
- Energy is required
- All of the above
Answer ✔ (a) Carrier is involved
Explanation: Facilitated diffusion differs from active transport in that it does not require energy source and it carries the transport in the direction of electrochemical gradient.
B. Pharma • Pharmacology • Bachelor of Pharmacy
34 of 36
Q.4 Acidic drugs mainly bind to plasma
- Albumin
- acid glycoprotein
- Weak acids
- Heparin & Protamine
Answer ✔ (a) Albumin
Explanation: Glycoprotein binds to basic drugs and albumin binds to many acidic drugs and a small number of basic drugs.
B. Pharma • Pharmacology • Bachelor of Pharmacy
35 of 36
Q.5 _______ is expressed in both the intestinal epithelium and the kidney.
- CYP378A
- CYP4B2
- CYP3A4
- CYP256
Answer ✔ (a) CYP378A
Explanation: CYP3A4 is involved in the metabolism of majority of drugs and is also expressed extrahepatically. In fact, poor bioavailability of many drugs is attributed to the drug metabolism by CYP3A4 in gastrointestinal tract.
B. Pharma • Pharmacology • Bachelor of Pharmacy
36 of 36
Q.6 N-oxidation will be involved with the metabolism of following drugs, except
- Dapsone
- Meperidine
- Phenytoin
- Chlorpheniramine
Answer ✔ (c) Phenytoin
Explanation: N-oxidation is involved in the metabolism of dapsone, meperidine and chloramphenicol. Metabolism of phenytoin involves oxidative Ndealkylation.
B. Pharma • Pharmacology • Bachelor of Pharmacy
Practice Tests All ❱
Online Practice Test for Pharmacy exams, previous Year questions
(50 Questions , 1233 attempts)
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