When both agonist and antagonist binds reversibly on the same site of the receptor
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the range of concentration of drug which produces desired response with minimal toxicity
Therapeutic window
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The enhancement of action of one drug by another inactive drug
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cancer that starts in the ectoderm or endoderm of epithelial cells of skin or the tissues that line other organs
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Antagonist binds with the same receptor as the agonist and inhibits its effect
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When two drugs act at different receptors or by different machanisms on the same physiological system and produce opposite effect
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In Sublingual route of drug administration Drug is absorbed through
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When two or more drugs on simultaneous administration show effect greater than that of either drug alone
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Chemical alteration of an agent (drug) that occurs by virtue of the sojourn of the agent in a biological system.
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Explanation:
CYP3A4 is involved in the metabolism of
majority of drugs and is also expressed
extrahepatically. In fact, poor bioavailability of
many drugs is attributed to the drug metabolism
by CYP3A4 in gastrointestinal tract.
