Vindesine Sulfate
Generic: Vindesine
Medicinal Chemistry
Molecular Weight
852.01
Molecular Formula
C43H55N5O7.H2SO4
IUPAC Name
(3R,5S,7R,9S)-9-[(3S,4R,5S,7R)-5-ethyl-5-hydroxy-4-methoxy-8-methyl-3-(methoxycarbonyl)-2,3,4,5,6,7,8,9-octahydro-1H-3,7-methano-1-benzazacycloundecin-9-yl]-5-ethyl-5-hydroxy-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indole-9-carboxamide sulfate
Pharmacognosy
Biological Source
Semi-synthetic from Catharanthus roseus (Madagascar Periwinkle)
Active Constituents
Vinblastine (Precursor)
Pharmacology & Synthesis
Mechanism of Action
Binds specifically to tubulin, inhibiting assembly of microtubules and arresting cells in metaphase.
Pharmacokinetics (ADME)
A: Administered IV only.
D: Moderate tissue binding.
M: Hepatic.
E: Biliary and fecal.
Pharmacodynamics
Cytotoxic to rapidly dividing cells; side effect profile is intermediate between vinblastine and vincristine.
Synthesis Pathway
Semi-synthetic derivative of vinblastine where the ester group is converted to an amide.
Safety, Warnings & Interactions
Adverse Effects
Myelosuppression, peripheral neuropathy, alopecia, GI toxicity.
Contraindications
Severe bone marrow suppression, active bacterial infection.
Drug Interactions
Ototoxic drugs, neurotoxic agents (additive effects).
Pharmaceutics & Compendia
Dosage Forms
Injection (as Vindesine Sulfate)
Official Compendia
BP, USP