Ajmalicine
Medicinal Chemistry
Molecular Weight
352.43
Molecular Formula
C21H24N2O3
IUPAC Name
Methyl (19alpha)-16,17-didehydro-19-methyl-oxayohimban-16-carboxylate
Pharmacognosy
Biological Source
Catharanthus roseus, Rauwolfia serpentina
Active Constituents
Ajmalicine (Raubasine)
Pharmacology & Synthesis
Mechanism of Action
Alpha-1 adrenergic receptor antagonist.
Pharmacokinetics (ADME)
A: Well absorbed.
D: Modest protein binding.
M: Hepatic.
E: Renal.
Pharmacodynamics
Causes peripheral vasodilation and lowers blood pressure.
Synthesis Pathway
Biosynthesized from tryptophan and secologanin via strictosidine.
Safety, Warnings & Interactions
Adverse Effects
Hypotension, dizziness, tachycardia.
Contraindications
Severe hypotension.
Drug Interactions
Other antihypertensives (additive effect).
Pharmaceutics & Compendia
Dosage Forms
Tablets