Arecoline
Medicinal Chemistry
Molecular Weight
155.19
Molecular Formula
C8H13NO2
IUPAC Name
Methyl 1-methyl-1,2,5,6-tetrahydropyridine-3-carboxylate
Pharmacognosy
Biological Source
Areca catechu
Active Constituents
Arecoline
Pharmacology & Synthesis
Mechanism of Action
Agonist at muscarinic acetylcholine receptors.
Pharmacokinetics (ADME)
A: Readily absorbed from buccal mucosa.
D: Crosses BBB.
M: Hepatic esterases.
E: Renal.
Pharmacodynamics
Causes central stimulation, miosis, increased glandular secretions.
Synthesis Pathway
Derived from nicotinic acid pathway.
Safety, Warnings & Interactions
Adverse Effects
Excessive salivation, sweating, bronchospasm, CNS stimulation.
Contraindications
Asthma, peptic ulcer, bradycardia.
Drug Interactions
Cholinesterase inhibitors, anticholinergics.
Pharmaceutics & Compendia
Dosage Forms
Veterinary Formulations