Ajmaline
Medicinal Chemistry
Molecular Weight
326.43
Molecular Formula
C20H26N2O2
IUPAC Name
(1R,9R,10S,13R,14R,16S,17S,18S,20S)-17-ethyl-1,10,13,14,15,16,17,18,19,20-decahydro-2H-2,14-methanoindolo[2,3-a]quinolizine-10,18-diol
Pharmacognosy
Biological Source
Rauwolfia serpentina
Active Constituents
Ajmaline
Pharmacology & Synthesis
Mechanism of Action
Class Ia antiarrhythmic; blocks sodium channels and prolongs cardiac action potential.
Pharmacokinetics (ADME)
A: Poor oral absorption, usually given IV.
D: Rapid tissue distribution.
M: Hepatic.
E: Renal and biliary.
Pharmacodynamics
Reduces cardiac conduction velocity, useful for Wolff-Parkinson-White syndrome.
Synthesis Pathway
Synthesized from tryptophan and secologanin via strictosidine.
Safety, Warnings & Interactions
Adverse Effects
Proarrhythmic effects, hypotension, bradycardia.
Contraindications
Heart block, severe bradycardia.
Drug Interactions
Other antiarrhythmics, beta-blockers.
Pharmaceutics & Compendia
Dosage Forms
Injection
Official Compendia
IP, BP