Vincamine Hydrochloride
Generic: Vincamine
Medicinal Chemistry
Molecular Weight
390.9
Molecular Formula
C21H26N2O3.HCl
IUPAC Name
Methyl (3alpha,14beta,16alpha)-14,15-dihydro-14-hydroxyeburnamenine-14-carboxylate hydrochloride
Pharmacognosy
Biological Source
Vinca minor (Lesser Periwinkle)
Active Constituents
Vincamine
Pharmacology & Synthesis
Mechanism of Action
Increases regional cerebral blood flow and acts as a mild phosphodiesterase type 1 (PDE1) inhibitor.
Pharmacokinetics (ADME)
A: Well absorbed orally.
D: Rapid tissue distribution.
M: Hepatic.
E: Renal.
Pharmacodynamics
Improves cerebral oxygenation and glucose utilization; used for cerebrovascular insufficiency.
Synthesis Pathway
Biosynthesized from strictosidine via geissoschizine and strictamine.
Safety, Warnings & Interactions
Adverse Effects
GI upset, mild hypotension, dry mouth.
Contraindications
Severe cardiac arrhythmias, acute stroke, brain neoplasms.
Drug Interactions
Additive effects with other hypotensive or vasodilating agents.
Pharmaceutics & Compendia
Dosage Forms
Capsules, Injection (as Vincamine Hydrochloride)
Official Compendia
BP