Vasicine Hydrochloride
Generic: Vasicine
Medicinal Chemistry
Molecular Weight
224.69
Molecular Formula
C11H12N2O.HCl
IUPAC Name
(3R)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol hydrochloride
Pharmacognosy
Biological Source
Justicia adhatoda (Malabar Nut, Vasaka)
Active Constituents
Vasicine, Vasicinone
Pharmacology & Synthesis
Mechanism of Action
Stimulates bronchodilation and acts as a respiratory stimulant and expectorant.
Pharmacokinetics (ADME)
A: Well absorbed orally.
D: Widely distributed in lung tissue.
M: Hepatic.
E: Renal.
Pharmacodynamics
Relieves bronchospasm, increases respiratory tract secretions (expectorant action).
Synthesis Pathway
Biosynthesized from anthranilic acid and putrescine.
Safety, Warnings & Interactions
Adverse Effects
Mild GI upset, hypotension at high doses.
Contraindications
Pregnancy (possesses oxytocic and abortifacient properties).
Drug Interactions
Additive effects with other bronchodilators.
Pharmaceutics & Compendia
Dosage Forms
Syrup (as Vasicine Hydrochloride), Herbal Extracts
Official Compendia
IP