Tubocurarine
Tubocurarine
Medicinal Chemistry
Molecular Weight
610.74
Molecular Formula
C37H42N2O6+2
IUPAC Name
(1beta,1'beta)-7',12'-dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyltubocuraran-2,2'-diium
Pharmacognosy
Biological Source
Chondrodendron tomentosum
Active Constituents
Tubocurarine
Pharmacology & Synthesis
Mechanism of Action
Non-depolarizing competitive antagonist at nicotinic receptors in the neuromuscular junction.
Pharmacokinetics (ADME)
A: Poor oral absorption (highly charged); given IV.
D: Extracellular fluid.
M: Hepatic (minimal).
E: Renal.
Pharmacodynamics
Causes rapid, flaccid skeletal muscle paralysis.
Synthesis Pathway
Derived from tyrosine.
Safety, Warnings & Interactions
Adverse Effects
Histamine release leading to hypotension and bronchospasm, prolonged apnea.
Contraindications
Myasthenia gravis, severe respiratory insufficiency.
Drug Interactions
Aminoglycosides, volatile anesthetics (enhance neuromuscular blockade).
Pharmaceutics & Compendia
Dosage Forms
Injection (historical)
Official Compendia
USP (historical)