Thebaine
Medicinal Chemistry
Molecular Weight
311.37
Molecular Formula
C19H21NO3
IUPAC Name
(5alpha)-6,7-didehydro-4,5-epoxy-3,6-dimethoxy-17-methylmorphinan
Pharmacognosy
Biological Source
Papaver somniferum, Papaver bracteatum
Active Constituents
Thebaine
Pharmacology & Synthesis
Mechanism of Action
Unlike morphine, it has stimulatory rather than depressant CNS effects; acts as a convulsant.
Pharmacokinetics (ADME)
A: Absorbed orally.
D: Widely distributed.
M: Hepatic.
E: Renal.
Pharmacodynamics
Causes strychnine-like convulsions at high doses; lacks significant analgesic activity.
Synthesis Pathway
Derived from reticuline.
Safety, Warnings & Interactions
Adverse Effects
Convulsions, muscle spasms.
Contraindications
Not used clinically for patient administration.
Drug Interactions
None.
Pharmaceutics & Compendia
Dosage Forms
Industrial Precursor (for Oxycodone/Naloxone)