Tetrandrine
Medicinal Chemistry
Molecular Weight
622.75
Molecular Formula
C38H42N2O6
IUPAC Name
(1beta,1'beta)-6,6',7,12-tetramethoxy-2,2'-dimethylberbaman
Pharmacognosy
Biological Source
Stephania tetrandra
Active Constituents
Tetrandrine
Pharmacology & Synthesis
Mechanism of Action
Blocks L-type and T-type voltage-gated calcium channels.
Pharmacokinetics (ADME)
A: Modest oral absorption.
D: Widely distributed.
M: Hepatic.
E: Biliary and fecal.
Pharmacodynamics
Causes vasodilation, lowers blood pressure, and exhibits potent anti-inflammatory effects.
Synthesis Pathway
Derived from tyrosine.
Safety, Warnings & Interactions
Adverse Effects
Hypotension, hepatotoxicity (often associated with impure botanical extracts).
Contraindications
Severe hypotension, hepatic impairment.
Drug Interactions
Other antihypertensive agents (additive effect).
Pharmaceutics & Compendia
Dosage Forms
Tablets (regional)