Sparteine
Medicinal Chemistry
Molecular Weight
234.38
Molecular Formula
C15H26N2
IUPAC Name
(7S,7aR,14S,14aR)-dodecahydro-1H-7,14-methanodipyrido[1,2-a:1',2'-e][1,5]diazocine
Pharmacognosy
Biological Source
Cytisus scoparius (Broom)
Active Constituents
Sparteine
Pharmacology & Synthesis
Mechanism of Action
Blocks voltage-gated sodium channels; also exhibits oxytocic (uterine stimulating) properties.
Pharmacokinetics (ADME)
A: Well absorbed.
D: Wide distribution.
M: Hepatic via CYP2D6 (polymorphic metabolism).
E: Renal.
Pharmacodynamics
Decreases cardiac conduction velocity; strongly stimulates uterine contractions.
Synthesis Pathway
Derived from lysine via cadaverine.
Safety, Warnings & Interactions
Adverse Effects
Bradycardia, visual disturbances, uterine rupture (if used during labor).
Contraindications
Pregnancy (causes severe fetal distress/rupture), heart block.
Drug Interactions
Other antiarrhythmics, beta-blockers.
Pharmaceutics & Compendia
Dosage Forms
Injection (historical)
Official Compendia
BP (historical)