Solanine
Medicinal Chemistry
Molecular Weight
868.04
Molecular Formula
C45H73NO15
IUPAC Name
(3beta)-solanid-5-en-3-yl O-6-deoxy-alpha-L-mannopyranosyl-(1->3)-O-[beta-D-glucopyranosyl-(1->2)]-beta-D-galactopyranoside
Pharmacognosy
Biological Source
Solanum tuberosum (Potato), Solanum nigrum
Active Constituents
Solanine
Pharmacology & Synthesis
Mechanism of Action
Inhibits cholinesterase activity and disrupts cell membranes.
Pharmacokinetics (ADME)
A: Poorly absorbed from GI tract.
D: Wide distribution.
M: Hepatic hydrolysis.
E: Fecal and renal.
Pharmacodynamics
Causes severe GI irritation and neurological symptoms upon ingestion.
Synthesis Pathway
Biosynthesized from cholesterol via a steroidal pathway.
Safety, Warnings & Interactions
Adverse Effects
Nausea, vomiting, diarrhea, hallucinations, paralysis, death.
Contraindications
Toxic; unfit for human consumption.
Drug Interactions
Cholinesterase inhibitors (additive toxicity).