Rescinnamine
Medicinal Chemistry
Molecular Weight
634.72
Molecular Formula
C35H42N2O9
IUPAC Name
Methyl (1R,15S,17R,18R,19S,20S)-11,17-dimethoxy-18-[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
Pharmacognosy
Biological Source
Rauwolfia serpentina
Active Constituents
Rescinnamine, Reserpine
Pharmacology & Synthesis
Mechanism of Action
Inhibits vesicular monoamine transporter (VMAT), depleting catecholamines in terminals.
Pharmacokinetics (ADME)
A: Moderate oral absorption.
D: Wide distribution.
M: Hepatic.
E: Fecal and renal.
Pharmacodynamics
Lowers blood pressure, causes central depression and sedation.
Synthesis Pathway
Biosynthesized from tryptophan.
Safety, Warnings & Interactions
Adverse Effects
Depression, sedation, bradycardia, nasal congestion, GI hypersecretion.
Contraindications
Active peptic ulcer, history of severe depression.
Drug Interactions
MAOIs, CNS depressants.
Pharmaceutics & Compendia
Dosage Forms
Tablets
Official Compendia
USP (historical)