Rauwolscine
Medicinal Chemistry
Molecular Weight
354.45
Molecular Formula
C21H26N2O3
IUPAC Name
Methyl (15alpha,20alpha)-17-hydroxyyohimban-16-carboxylate
Pharmacognosy
Biological Source
Rauwolfia serpentina
Active Constituents
Rauwolscine
Pharmacology & Synthesis
Mechanism of Action
Alpha-2 adrenergic receptor antagonist (diastereomer of yohimbine).
Pharmacokinetics (ADME)
A: Well absorbed.
D: Crosses BBB.
M: Hepatic.
E: Renal.
Pharmacodynamics
Increases sympathetic outflow, mild CNS stimulant.
Synthesis Pathway
Derived from tryptamine and secologanin.
Safety, Warnings & Interactions
Adverse Effects
Anxiety, tachycardia, elevated blood pressure.
Contraindications
Severe cardiovascular disease, renal failure.
Drug Interactions
Antihypertensives (antagonism).
Pharmaceutics & Compendia
Dosage Forms
Extracts