Quinidine
Medicinal Chemistry
Molecular Weight
324.42
Molecular Formula
C20H24N2O2
IUPAC Name
(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]oct-2-yl](6-methoxyquinolin-4-yl)methanol
Pharmacognosy
Biological Source
Cinchona species
Active Constituents
Quinidine
Pharmacology & Synthesis
Mechanism of Action
Blocks fast inward sodium channels, prolonging action potential duration.
Pharmacokinetics (ADME)
A: Rapidly absorbed.
D: High protein binding.
M: Hepatic.
E: Renal.
Pharmacodynamics
Decreases myocardial excitability and conduction velocity.
Synthesis Pathway
Stereoisomer of quinine, derived from strictosidine.
Safety, Warnings & Interactions
Adverse Effects
Diarrhea, cinchonism, proarrhythmic (Torsades de pointes).
Contraindications
Complete heart block, prolonged QT interval.
Drug Interactions
Digoxin (increases levels), amiodarone.
Pharmaceutics & Compendia
Dosage Forms
Tablets, Injection
Official Compendia
IP, BP, USP