Psilocybin
Medicinal Chemistry
Molecular Weight
284.25
Molecular Formula
C12H17N2O4P
IUPAC Name
[3-[2-(dimethylamino)ethyl]-1H-indol-4-yl] dihydrogen phosphate
Pharmacognosy
Biological Source
Psilocybe cubensis
Active Constituents
Psilocybin, Psilocin
Pharmacology & Synthesis
Mechanism of Action
Prodrug; dephosphorylated to psilocin, which acts as a 5-HT2A partial agonist.
Pharmacokinetics (ADME)
A: Well absorbed orally.
D: Crosses BBB rapidly.
M: Hepatic alkaline phosphatase to psilocin.
E: Renal.
Pharmacodynamics
Alters cognition, perception, and mood; mystical experiences.
Synthesis Pathway
Biosynthesized from tryptophan.
Safety, Warnings & Interactions
Adverse Effects
Anxiety, paranoia, nausea, transient hypertension.
Contraindications
Psychiatric disorders (schizophrenia, bipolar).
Drug Interactions
SSRIs (attenuate effects), MAOIs (prolong effects).
Pharmaceutics & Compendia
Dosage Forms
Dried mushrooms, Capsules