Pseudoephedrine
Medicinal Chemistry
Molecular Weight
165.23
Molecular Formula
C10H15NO
IUPAC Name
(1S,2S)-2-(methylamino)-1-phenylpropan-1-ol
Pharmacognosy
Biological Source
Ephedra sinica
Active Constituents
Pseudoephedrine, Ephedrine
Pharmacology & Synthesis
Mechanism of Action
Direct alpha-adrenergic agonist and stimulates release of norepinephrine.
Pharmacokinetics (ADME)
A: Well absorbed orally.
D: Crosses BBB (less than ephedrine).
M: Minimal hepatic (N-demethylation).
E: Renal (unchanged).
Pharmacodynamics
Potent vasoconstrictor of respiratory mucosa (decongestant); weaker CNS stimulant than ephedrine.
Synthesis Pathway
Biosynthesized from phenylalanine.
Safety, Warnings & Interactions
Adverse Effects
Insomnia, tachycardia, hypertension, urinary retention.
Contraindications
Severe hypertension, coronary artery disease, MAOI therapy.
Drug Interactions
MAOIs (hypertensive crisis), beta-blockers.
Pharmaceutics & Compendia
Dosage Forms
Tablets, Syrups
Official Compendia
IP, BP, USP