Pelletierine
Medicinal Chemistry
Molecular Weight
141.21
Molecular Formula
C8H15NO
IUPAC Name
1-(piperidin-2-yl)propan-1-one
Pharmacognosy
Biological Source
Punica granatum (Pomegranate)
Active Constituents
Pelletierine, Isopelletierine
Pharmacology & Synthesis
Mechanism of Action
Acts as a specific neurotoxin to tapeworms.
Pharmacokinetics (ADME)
A: Poor absorption, acts locally.
D: Localized to GI tract.
M: Minimal.
E: Fecal.
Pharmacodynamics
Paralyzes intestinal tapeworms.
Synthesis Pathway
Derived from lysine.
Safety, Warnings & Interactions
Adverse Effects
Dizziness, visual disturbances, vomiting.
Contraindications
Pregnancy.
Drug Interactions
Other anthelmintic agents.
Pharmaceutics & Compendia
Dosage Forms
Extracts