Noscapine
Medicinal Chemistry
Molecular Weight
413.42
Molecular Formula
C22H23NO7
IUPAC Name
(3S)-6,7-dimethoxy-3-[(5R)-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
Pharmacognosy
Biological Source
Papaver somniferum (Opium poppy)
Active Constituents
Noscapine
Pharmacology & Synthesis
Mechanism of Action
Sigma receptor agonist; suppresses cough reflex without opioid receptor binding.
Pharmacokinetics (ADME)
A: Good oral absorption.
D: Extensive tissue distribution.
M: Hepatic.
E: Renal and biliary.
Pharmacodynamics
Central antitussive action; lacks analgesic, sedative, and respiratory depressant effects.
Synthesis Pathway
Derived from tyrosine via reticuline.
Safety, Warnings & Interactions
Adverse Effects
Nausea, headache, dizziness.
Contraindications
First trimester of pregnancy.
Drug Interactions
Mild additive sedation with other CNS depressants.
Pharmaceutics & Compendia
Dosage Forms
Syrups, Tablets, Linctus
Official Compendia
IP, BP, USP