Narceine
Medicinal Chemistry
Molecular Weight
445.47
Molecular Formula
C23H27NO8
IUPAC Name
3-[6-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-1,3-benzodioxol-5-yl]-1-(4,5-dimethoxy-2-hydroxyphenyl)propan-1-one
Pharmacognosy
Biological Source
Papaver somniferum
Active Constituents
Narceine, Morphine
Pharmacology & Synthesis
Mechanism of Action
Weak opioid receptor affinity; mild antitussive and analgesic properties.
Pharmacokinetics (ADME)
A: Well absorbed.
D: Widely distributed.
M: Hepatic.
E: Renal.
Pharmacodynamics
Produces mild sedation and cough suppression; less potent than codeine.
Synthesis Pathway
Formed by oxidative degradation of noscapine/narcotine.
Safety, Warnings & Interactions
Adverse Effects
Drowsiness, mild constipation.
Contraindications
Severe respiratory depression.
Drug Interactions
CNS depressants.
Pharmaceutics & Compendia
Dosage Forms
Historical formulations