Methylergometrine
Medicinal Chemistry
Molecular Weight
339.44
Molecular Formula
C20H25N3O2
IUPAC Name
(8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide
Pharmacognosy
Biological Source
Semi-synthetic from Lysergic acid
Active Constituents
Lysergic acid (precursor)
Pharmacology & Synthesis
Mechanism of Action
Partial agonist/antagonist at serotonergic, dopaminergic, and alpha-adrenergic receptors.
Pharmacokinetics (ADME)
A: Rapid and complete oral/IM absorption.
D: Widely distributed.
M: Hepatic.
E: Renal and fecal.
Pharmacodynamics
Increases motor activity of the uterus (tone, rate, and amplitude of contractions).
Synthesis Pathway
Semi-synthetic derivative of naturally occurring ergot alkaloids.
Safety, Warnings & Interactions
Adverse Effects
Hypertension, headache, nausea, seizures.
Contraindications
Pregnancy (prior to delivery), severe hypertension, eclampsia.
Drug Interactions
CYP3A4 inhibitors (macrolides, azoles), triptans.
Pharmaceutics & Compendia
Dosage Forms
Tablets, Injection
Official Compendia
IP, BP, USP