Lycorine
Medicinal Chemistry
Molecular Weight
287.31
Molecular Formula
C16H17NO4
IUPAC Name
(1R,2S,12bS)-1,2,4,5,7,12b-hexahydro-1,2-di-hydroxy-3H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine
Pharmacognosy
Biological Source
Narcissus pseudonarcissus, Lycoris radiata
Active Constituents
Lycorine
Pharmacology & Synthesis
Mechanism of Action
Inhibits protein synthesis and ascorbate biosynthesis; induces apoptosis.
Pharmacokinetics (ADME)
A: Rapidly absorbed orally.
D: Widely distributed.
M: Hepatic.
E: Renal.
Pharmacodynamics
Potent emetic action; exhibits antiviral and antineoplastic properties in vitro.
Synthesis Pathway
Biosynthesized from tyrosine via norbelladine.
Safety, Warnings & Interactions
Adverse Effects
Severe vomiting, diarrhea, tremors, paralysis.
Contraindications
Not used clinically.
Drug Interactions
None.