Jervine
Medicinal Chemistry
Molecular Weight
425.61
Molecular Formula
C27H39NO3
IUPAC Name
(3beta,22S,23R)-17,23-epoxy-3-hydroxyveratraman-11-one
Pharmacognosy
Biological Source
Veratrum album, Veratrum californicum
Active Constituents
Jervine, Cyclopamine
Pharmacology & Synthesis
Mechanism of Action
Inhibits the Hedgehog signaling pathway by binding to Smoothened (SMO).
Pharmacokinetics (ADME)
A: Absorbed from GI tract.
D: Widely distributed, crosses placenta.
M: Hepatic.
E: Fecal.
Pharmacodynamics
Causes severe congenital deformities (cyclopia) during fetal development.
Synthesis Pathway
Biosynthesized from cholesterol.
Safety, Warnings & Interactions
Adverse Effects
Severe birth defects, hypotension, respiratory depression.
Contraindications
Pregnancy (strictly contraindicated).
Drug Interactions
None clinically relevant (toxic agent).