Isopelletierine
Medicinal Chemistry
Molecular Weight
141.21
Molecular Formula
C8H15NO
IUPAC Name
1-(piperidin-2-yl)propan-2-one
Pharmacognosy
Biological Source
Punica granatum (Pomegranate root bark)
Active Constituents
Isopelletierine, Pelletierine
Pharmacology & Synthesis
Mechanism of Action
Acts as a neurotoxin to tapeworms, causing paralysis of the parasite.
Pharmacokinetics (ADME)
A: Poorly absorbed, acts locally in the GI tract.
D: Localized in GI.
M: Minimal.
E: Fecal.
Pharmacodynamics
Expels tapeworms by causing their detachment from the intestinal wall.
Synthesis Pathway
Derived from lysine via delta-1-piperideine.
Safety, Warnings & Interactions
Adverse Effects
Nausea, vomiting, dizziness, visual disturbances.
Contraindications
Pregnancy, GI ulceration.
Drug Interactions
Other anthelmintics.
Pharmaceutics & Compendia
Dosage Forms
Decoctions, Extracts