Hydrastine
Medicinal Chemistry
Molecular Weight
383.4
Molecular Formula
C21H21NO6
IUPAC Name
(3R)-6,7-dimethoxy-3-[(5S)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-2-benzofuran-1(3H)-one
Pharmacognosy
Biological Source
Hydrastis canadensis (Goldenseal)
Active Constituents
Hydrastine, Berberine
Pharmacology & Synthesis
Mechanism of Action
Vasoconstrictor, inhibits GABA-A receptors.
Pharmacokinetics (ADME)
A: Good oral absorption.
D: Widely distributed.
M: Hepatic.
E: Renal.
Pharmacodynamics
Constricts blood vessels, historically used as a hemostatic agent.
Synthesis Pathway
Biosynthesized from tyrosine.
Safety, Warnings & Interactions
Adverse Effects
Hypertension, seizures (at high doses).
Contraindications
Pregnancy, hypertension.
Drug Interactions
CNS stimulants.
Pharmaceutics & Compendia
Dosage Forms
Tinctures, Extracts
Official Compendia
USP (historical)