Homatropine
Medicinal Chemistry
Molecular Weight
275.35
Molecular Formula
C16H21NO3
IUPAC Name
(8-methyl-8-azabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenylacetate
Pharmacognosy
Biological Source
Semi-synthetic derivative of Tropine
Active Constituents
Tropine (precursor)
Pharmacology & Synthesis
Mechanism of Action
Competitive antagonist at muscarinic acetylcholine receptors.
Pharmacokinetics (ADME)
A: Readily absorbed.
D: Wide distribution.
M: Hepatic.
E: Renal.
Pharmacodynamics
Produces mydriasis and cycloplegia (shorter acting than atropine).
Synthesis Pathway
Esterification of tropine with mandelic acid.
Safety, Warnings & Interactions
Adverse Effects
Blurred vision, dry mouth, photophobia, tachycardia.
Contraindications
Narrow-angle glaucoma.
Drug Interactions
Other anticholinergics.
Pharmaceutics & Compendia
Dosage Forms
Ophthalmic drops, Syrups
Official Compendia
USP