Harmine
Medicinal Chemistry
Molecular Weight
212.25
Molecular Formula
C13H12N2O
IUPAC Name
7-methoxy-1-methyl-9H-pyrido[3,4-b]indole
Pharmacognosy
Biological Source
Peganum harmala, Banisteriopsis caapi
Active Constituents
Harmine
Pharmacology & Synthesis
Mechanism of Action
Reversible inhibitor of MAO-A; intercalates with DNA.
Pharmacokinetics (ADME)
A: Readily absorbed.
D: Crosses BBB.
M: Hepatic.
E: Renal.
Pharmacodynamics
Elevates monoamines, contributes to the psychoactive effects of Ayahuasca.
Synthesis Pathway
Biosynthesized from tryptophan.
Safety, Warnings & Interactions
Adverse Effects
Tremors, nausea, psychoactive effects.
Contraindications
Co-administration with SSRIs.
Drug Interactions
SSRIs, other serotonergic drugs.
Pharmaceutics & Compendia
Dosage Forms
Plant extracts