Glaucine
Medicinal Chemistry
Molecular Weight
355.43
Molecular Formula
C21H25NO4
IUPAC Name
(S)-1,2,9,10-tetramethoxyaporphine
Pharmacognosy
Biological Source
Glaucium flavum (Yellow hornpoppy)
Active Constituents
Glaucine
Pharmacology & Synthesis
Mechanism of Action
Central antitussive action, mild bronchodilator, weak PDE4 inhibitor.
Pharmacokinetics (ADME)
A: Well absorbed orally.
D: Widely distributed.
M: Hepatic.
E: Renal.
Pharmacodynamics
Suppresses cough reflex without causing significant sedation or addiction.
Synthesis Pathway
Synthesized from reticuline.
Safety, Warnings & Interactions
Adverse Effects
Mild drowsiness, dizziness, hypotension at high doses.
Contraindications
Severe hypotension, productive cough.
Drug Interactions
Antihypertensives (additive hypotension).
Pharmaceutics & Compendia
Dosage Forms
Syrups, Tablets
Official Compendia
BP