Evodiamine
Medicinal Chemistry
Molecular Weight
303.36
Molecular Formula
C19H17N3O
IUPAC Name
(3Z)-14-methyl-8,13,13b,14-tetrahydro-7H-indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5-one
Pharmacognosy
Biological Source
Evodia rutaecarpa
Active Constituents
Evodiamine, Rutaecarpine
Pharmacology & Synthesis
Mechanism of Action
Agonist of transient receptor potential vanilloid 1 (TRPV1), stimulating sympathetic nervous system.
Pharmacokinetics (ADME)
A: Moderate absorption.
D: Distributed widely.
M: Hepatic.
E: Fecal and renal.
Pharmacodynamics
Increases heat production, mildly stimulates CNS.
Synthesis Pathway
Derived from tryptophan and anthranilic acid.
Safety, Warnings & Interactions
Adverse Effects
Mild cardiovascular stimulation, GI upset.
Contraindications
Severe cardiovascular disorders.
Drug Interactions
Synergistic with caffeine and other stimulants.
Pharmaceutics & Compendia
Dosage Forms
Herbal supplements, Extracts