Deserpidine
Medicinal Chemistry
Molecular Weight
578.66
Molecular Formula
C32H38N2O8
IUPAC Name
Methyl (1R,15S,17R,18R,19S,20S)-17-(3,4,5-trimethoxybenzoyloxy)-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
Pharmacognosy
Biological Source
Rauwolfia canescens
Active Constituents
Deserpidine
Pharmacology & Synthesis
Mechanism of Action
Irreversibly blocks VMAT, depleting monoamines (NE, DA, 5-HT) in synapses.
Pharmacokinetics (ADME)
A: Moderately absorbed.
D: Crosses BBB.
M: Hepatic.
E: Fecal and renal.
Pharmacodynamics
Lowers blood pressure, produces sedation.
Synthesis Pathway
Biosynthesized from tryptophan and secologanin.
Safety, Warnings & Interactions
Adverse Effects
Depression, bradycardia, nasal congestion, GI hypersecretion.
Contraindications
Active peptic ulcer, history of depression.
Drug Interactions
MAOIs, CNS depressants.
Pharmaceutics & Compendia
Dosage Forms
Tablets
Official Compendia
USP