Cytisine
Medicinal Chemistry
Molecular Weight
190.25
Molecular Formula
C11H14N2O
IUPAC Name
(1R,5S)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
Pharmacognosy
Biological Source
Cytisus laborinum, Laburnum anagyroides
Active Constituents
Cytisine
Pharmacology & Synthesis
Mechanism of Action
Partial agonist at alpha-4 beta-2 nicotinic acetylcholine receptors.
Pharmacokinetics (ADME)
A: Well absorbed orally.
D: Wide distribution.
M: Minimal hepatic.
E: Renal (largely unchanged).
Pharmacodynamics
Reduces nicotine craving and withdrawal symptoms.
Synthesis Pathway
Biosynthesized from lysine via cadaverine.
Safety, Warnings & Interactions
Adverse Effects
Nausea, vomiting, dizziness, sleep disturbances.
Contraindications
Unstable angina, recent MI, pregnancy.
Drug Interactions
Synergistic toxicity with nicotine.
Pharmaceutics & Compendia
Dosage Forms
Tablets
Official Compendia
BP