Coniine
Medicinal Chemistry
Molecular Weight
127.23
Molecular Formula
C8H17N
IUPAC Name
(2S)-2-propylpiperidine
Pharmacognosy
Biological Source
Conium maculatum (Poison hemlock)
Active Constituents
Coniine, gamma-coniceine
Pharmacology & Synthesis
Mechanism of Action
Antagonist at nicotinic acetylcholine receptors.
Pharmacokinetics (ADME)
A: Rapidly absorbed.
D: Widely distributed.
M: Hepatic.
E: Renal.
Pharmacodynamics
Causes ascending muscular paralysis, eventually affecting respiratory muscles.
Synthesis Pathway
Biosynthesized from acetate via polyketide pathway.
Safety, Warnings & Interactions
Adverse Effects
Paralysis, respiratory failure, death.
Contraindications
Not used clinically.
Drug Interactions
None.