Chelidonine
Medicinal Chemistry
Molecular Weight
353.37
Molecular Formula
C20H19NO5
IUPAC Name
(5bR,6Z,12bS)-13-methyl-5b,6,7,12b,13,14-hexahydro[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-6-ol
Pharmacognosy
Biological Source
Chelidonium majus
Active Constituents
Chelidonine
Pharmacology & Synthesis
Mechanism of Action
Papavarine-like spasmolytic action; acts on smooth muscle.
Pharmacokinetics (ADME)
A: Moderate oral absorption.
D: Widely distributed.
M: Hepatic.
E: Biliary and renal.
Pharmacodynamics
Relaxes GI and biliary smooth muscle, mild analgesic.
Synthesis Pathway
Derived from tyrosine.
Safety, Warnings & Interactions
Adverse Effects
Hepatotoxicity (at high doses).
Contraindications
Liver disease, pregnancy.
Drug Interactions
Hepatotoxic drugs.
Pharmaceutics & Compendia
Dosage Forms
Extracts, Tinctures