Cathinone
Medicinal Chemistry
Molecular Weight
149.19
Molecular Formula
C9H11NO
IUPAC Name
(S)-2-amino-1-phenylpropan-1-one
Pharmacognosy
Biological Source
Catha edulis (Khat)
Active Constituents
Cathinone
Pharmacology & Synthesis
Mechanism of Action
Promotes release of dopamine and norepinephrine; inhibits their reuptake.
Pharmacokinetics (ADME)
A: Readily absorbed from buccal mucosa (chewing).
D: Crosses BBB.
M: Hepatic to cathine.
E: Renal.
Pharmacodynamics
Euphoria, increased alertness, anorexia, tachycardia.
Synthesis Pathway
Derived from phenylalanine.
Safety, Warnings & Interactions
Adverse Effects
Anxiety, insomnia, hypertension, dependence.
Contraindications
Cardiovascular disease, psychiatric disorders.
Drug Interactions
MAOIs, other CNS stimulants.
Pharmaceutics & Compendia
Dosage Forms
Raw plant material