Brucine
Medicinal Chemistry
Molecular Weight
394.46
Molecular Formula
C23H26N2O4
IUPAC Name
2,3-dimethoxystrychnidin-10-one
Pharmacognosy
Biological Source
Strychnos nux-vomica
Active Constituents
Brucine
Pharmacology & Synthesis
Mechanism of Action
Competitive antagonist of glycine receptors in the spinal cord (less potent than strychnine).
Pharmacokinetics (ADME)
A: Readily absorbed.
D: Widely distributed.
M: Hepatic.
E: Renal.
Pharmacodynamics
Causes muscle spasms and convulsions.
Synthesis Pathway
Biosynthesized from tryptophan and secologanin.
Safety, Warnings & Interactions
Adverse Effects
Muscle spasms, convulsions, hyperreflexia.
Contraindications
Not used clinically.
Drug Interactions
None.