Boldine
Medicinal Chemistry
Molecular Weight
327.37
Molecular Formula
C19H21NO4
IUPAC Name
(S)-2,9-dihydroxy-1,10-dimethoxyaporphine
Pharmacognosy
Biological Source
Peumus boldus
Active Constituents
Boldine
Pharmacology & Synthesis
Mechanism of Action
Potent antioxidant and free radical scavenger; protects against oxidative damage.
Pharmacokinetics (ADME)
A: Well absorbed.
D: Distributed rapidly.
M: Hepatic.
E: Renal and biliary.
Pharmacodynamics
Hepatoprotective and choleretic effects.
Synthesis Pathway
Derived from reticuline.
Safety, Warnings & Interactions
Adverse Effects
Generally well tolerated; high doses may cause cramps.
Contraindications
Severe liver disease, biliary obstruction.
Drug Interactions
Potential interactions with hepatotoxic drugs.
Pharmaceutics & Compendia
Dosage Forms
Extracts, Supplements