Bicuculline
Medicinal Chemistry
Molecular Weight
367.35
Molecular Formula
C20H17NO6
IUPAC Name
(6R)-6-[(5S)-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]furo[3,4-e][1,3]benzodioxol-8(6H)-one
Pharmacognosy
Biological Source
Dicentra cucullaria
Active Constituents
Bicuculline
Pharmacology & Synthesis
Mechanism of Action
Competitive antagonist at GABA-A receptors.
Pharmacokinetics (ADME)
A: Rapidly absorbed.
D: Crosses BBB easily.
M: Hepatic.
E: Renal.
Pharmacodynamics
Induces convulsions by blocking inhibitory GABAergic transmission.
Synthesis Pathway
Synthesized from tyrosine derivatives.
Safety, Warnings & Interactions
Adverse Effects
Convulsions, seizures, death.
Contraindications
Not used clinically (used in research).
Drug Interactions
GABA agonists (antagonism).