Ibogaine
Medicinal Chemistry
Molecular Weight
310.44
Molecular Formula
C20H26N2O
IUPAC Name
12-methoxy-ibogamine
Pharmacognosy
Biological Source
Tabernanthe iboga
Active Constituents
Ibogaine, Ibogamine
Pharmacology & Synthesis
Mechanism of Action
NMDA receptor antagonist; interacts with serotonin and sigma-2 receptors.
Pharmacokinetics (ADME)
A: Rapid oral absorption.
D: Highly lipophilic, concentrates in fat/brain.
M: Hepatic via CYP2D6 to active noribogaine.
E: Renal and fecal.
Pharmacodynamics
Induces a dream-like hallucinogenic state; disrupts addiction circuits.
Synthesis Pathway
Biosynthesized from tryptamine and secologanin.
Safety, Warnings & Interactions
Adverse Effects
Ataxia, tremors, severe QT prolongation, neurotoxicity.
Contraindications
Cardiovascular disease, psychiatric history.
Drug Interactions
QT-prolonging drugs, CYP2D6 inhibitors.
Pharmaceutics & Compendia
Dosage Forms
Extracts, Capsules