Colchicine
Medicinal Chemistry
Molecular Weight
399.44
Molecular Formula
C22H25NO6
IUPAC Name
N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Pharmacognosy
Biological Source
Colchicum autumnale
Active Constituents
Colchicine
Pharmacology & Synthesis
Mechanism of Action
Binds to tubulin, inhibiting microtubule polymerization and neutrophil motility.
Pharmacokinetics (ADME)
A: Rapidly absorbed.
D: Concentrates in leukocytes.
M: Hepatic CYP3A4.
E: Biliary and renal.
Pharmacodynamics
Reduces inflammation in acute gout flares.
Synthesis Pathway
Synthesized from phenylalanine and tyrosine.
Safety, Warnings & Interactions
Adverse Effects
Severe diarrhea, nausea, bone marrow suppression.
Contraindications
Severe renal/hepatic impairment.
Drug Interactions
Strong CYP3A4 or P-gp inhibitors (clarithromycin).
Pharmaceutics & Compendia
Dosage Forms
Tablets, Capsules
Official Compendia
IP, BP, USP