Why do ACE inhibitors such as enalapril cause persistent dry cough?

Inhibition of kinase II leading to the accumulation of pulmonary bradykinin and substance P

Direct bronchial smooth muscle stimulation via AT1 receptor activation

Excessive accumulation of circulating angiotensin I in the alveolar parenchyma

Suppression of renal prostaglandin E2 synthesis

What is the main action of ARBs such as losartan?

Selective competitive antagonism at the Angiotensin II Type 1 (AT1) receptor subtype

Irreversible covalent inactivation of renal juxtaglomerular renin granules

Competitive inhibition of the active zinc domain of kininase II

Direct stimulation of central imidazoline I1 receptors in the medulla

Why is verapamil useful in supraventricular tachycardia (SVT)?

Verapamil exerts potent inhibitory effects on voltage-gated L-type calcium channels in the AV node, slowing conduction velocity

Verapamil selectively opens vascular ATP-sensitive potassium channels

Verapamil acts as a competitive antagonist at cardiac beta-1 adrenergic receptors

Verapamil causes marked arterial vasodilation that triggers reflex tachycardia

What is furosemide’s site and target of action in the nephron?

Inhibition of the Na+/K+/2Cl- cotransporter (NKCC2) in the thick ascending limb of the loop of Henle

Competitive antagonism of mineralocorticoid receptors in the cortical collecting duct

Blockade of the Na+/Cl- symporter (NCC) in the early distal convoluted tubule

Inhibition of apical epithelial sodium channels (ENaC) in the late distal tubule

Which effect distinguishes loop diuretics from thiazides regarding urinary calcium?

Increased urinary calcium excretion (hypercalciuria)

Where do thiazide diuretics act, and which transporter do they inhibit?

Inhibition of the electroneutral Na+/Cl- cotransporter (NCC) in the distal convoluted tubule

Blockade of apical aquaporin-2 water channels in the medullary collecting duct

Inhibition of basolateral Na+/K+-ATPase in the collecting duct

Inhibition of the Na+/H+ exchanger (NHE3) in the proximal convoluted tubule

Which metabolic effects are associated with long-term/high-dose thiazide use?

Hypokalemia, hyperglycemia, and hyperuricemia

Hyperkalemia, metabolic acidosis, and hypocalcemia

Hyponatremia, hypoglycemia, and hypercalcemia

Hyperkalemia, hypoglycemia, and hypouricemia

How does spironolactone act as a potassium-sparing diuretic?

Competitive antagonism of cytosolic Mineralocorticoid (Aldosterone) Receptors in principal cells

Direct blockade of the apical Epithelial Sodium Channel (ENaC)

Competitive inhibition of the renal Na+/K+/2Cl- symporter

Inhibition of renal tubular Carbonic Anhydrase type II

Which endocrine adverse effects can spironolactone cause?

Gynecomastia and menstrual irregularities

What is digoxin’s primary molecular target in cardiac cells?

Reversible inhibition of the sarcolemmal Na+/K+-ATPase enzyme pump

Opening of mitochondrial ATP-sensitive potassium channels

Allosteric stimulation of the sarcoplasmic reticulum Ca2+-ATPase (SERCA2a)

Direct agonism at cardiac beta-1 adrenergic receptors

How does digoxin increase cardiac contractility?

Accumulation of intracellular Na+ reduces the trans-sarcolemmal Na+ gradient, slowing Ca2+ extrusion via the 3Na+/1Ca2+ antiporter

Depletion of intracellular potassium directly triggers calcium influx through T-type channels

Elevated extracellular sodium activates voltage-dependent L-type calcium channels continuously

Direct enzymatic phosphorylation of troponin C increases its binding affinity for actin

Which visual disturbance is classically associated with digoxin toxicity?

Xanthopsia (yellow-green colored vision with halo effects)

Central retinal vein occlusion with loss of red-green vision

Tunnel vision with bilateral optic disc edema

What is the specific antidote for life-threatening digoxin overdose?

Digoxin-specific antigen-binding fragments (DigiFab / Digibind)

Oral activated charcoal with high-dose potassium citrate

Intravenous Atropine combined with Quinidine sulfate

How does nitroglycerin produce vascular smooth-muscle relaxation?

Biotransformation into Nitric Oxide (NO) by mitochondrial aldehyde dehydrogenase-2 (ALDH2), activating soluble Guanylyl Cyclase

Inhibition of vascular phosphodiesterase type 3 (PDE3)

Direct competitive blockade of postjunctional vascular Alpha-1 adrenergic receptors

Allosteric opening of vascular voltage-dependent calcium channels

What is nitroglycerin’s main hemodynamic effect in exertional angina?

Potent systemic venous dilation (venodilation) reducing venous return, ventricular preload, and myocardial wall tension

Direct blockade of cardiac pacemaker 'funny' channels (If) to reduce heart rate

Selective dilation of intracranial cerebral arterioles

Marked peripheral arteriolar constriction to increase coronary perfusion pressure

What serious interaction occurs with nitrates and PDE5 inhibitors?

Profound, refractory systemic hypotension and cardiovascular collapse

Complete AV block with marked PR prolongation

Sudden coronary spasm through thromboxane A2 release

Acute hypertensive crisis mediated by rebound catecholamine release

What is the loss of nitrate effectiveness during continuous therapy called?

Nitrate tolerance due to reduced bioactivation and oxidative stress

Precipitation of inactive nitrate crystals within coronary endothelial cells

Rapid upregulation of vascular phosphodiesterase-5 enzymes

Competitive displacement of nitrates from plasma albumin by endogenous fatty acids

How does ranolazine treat chronic stable angina?

Selective blockade of the late inward sodium current (late INa), reducing intracellular calcium overload in ischemic myocytes

Direct competitive antagonism of vascular endothelin ET-A receptors

Potent stimulation of sarcolemmal K-ATP channels causing coronary hyperpolarization

Inhibition of beta-oxidation of fatty acids in cardiomyocyte mitochondria

Which enzyme do statins competitively inhibit in cholesterol synthesis?

HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

Acyl-CoA cholesterol acyltransferase (ACAT)

How does sodium nitroprusside lower blood pressure in hypertensive emergencies?

Non-enzymatic spontaneous release of Nitric Oxide (NO) in blood, relaxing both arterioles and venules

Selective agonism at peripheral dopamine D1 receptors

Direct activation of vascular smooth muscle K-ATP channels

Competitive blockade of endothelin-1 receptors

★★★★★No reviews yet

RRB PH UT12 – Pharmacology Practice Test 4: Cardiovascular & Renal Systems

Diksha Bhatla November 13, 2026 21 views 30 Questions

Download PDF

🎯 Practice: Earn +4 Pts for right answers, auto-save wrong ones (-1 Pt) to your Mistake Bank & unlock +50 Daily Bonus! Login to Track Streak →

⚡

Practice Mode (+4 / -1 Pts)

Solve instantly below with live points (+4 Right, -1 Wrong), detailed explanations & Mistake Bank sync.

Start Practice ↓

🎯

Full Exam Mode

Take this test in a strict timed environment with negative marking and detailed analytics.

Take Assessment →

🔒 Premium Assessment Locked

This test is part of a premium package. Unlock it to access practice questions, detailed explanations, and full exam mode.

RRB Pharmacist 2026 56 tests in this series · Click to view included tests ₹149 ₹299

Buy Series

RRB PM-UT 01 – Anatomy & Physiology Test 1: Cells, Tissues & Skeletal System
Premium (₹9)

View Details
RRB PM-UT 02 – Anatomy & Physiology Practice Test 2: Cardiovascular & Lymphatic Systems
Premium (₹9)

View Details
RRB PM-UT 03 – Anatomy & Physiology Practice Test 3: Respiratory & Excretory Systems
Premium (₹9)

View Details
RRB PM-UT04 – Anatomy & Physiology Practice Test 4: Nervous & Endocrine Systems
Premium (₹9)

View Details
RRB PH UT05 | Pharmaceutics Practice Test 1: Liquid Dosage Forms
Premium (₹9)

View Details
RRB PH UT06 – Pharmaceutics Practice Test 2: Semisolid Dosage Forms
Premium (₹9)

View Details
RRB PH UT07 – Pharmaceutics Practice Test 3: Solid Dosage Forms (Tablets & Capsules)
Premium (₹9)

View Details
RRB PH UT08 – Pharmaceutics Practice Test 4: Posology & Packaging
Premium (₹9)

View Details
RRB PH UT09 – Pharmacology Practice Test 1: General Pharmacology & Pharmacokinetics
Premium (₹9)

View Details
RRB PH UT10 – Pharmacology Practice Test 10: Autonomic Nervous System (ANS)
Premium (₹9)

View Details
RRB PH UT11 – Pharmacology Practice Test 3: Central Nervous System (CNS)
Premium (₹9)

View Details
RRB PH UT12 – Pharmacology Practice Test 4: Cardiovascular & Renal Systems (Currently Viewing)
Premium (₹9)

Live Assessment
RRB PH UT13 – Pharmacology Practice Test 5: Chemotherapy, Antimicrobials & Toxicology
Premium (₹9)

View Details
RRB PH UT14 – Pharmaceutical Chemistry Practice Test 1: Inorganic Chemistry & Limit Tests
Premium (₹9)

View Details
RRB PH UT15 – Pharmaceutical Chemistry Practice Test 2: Organic Chemistry & Heterocycles
Premium (₹9)

View Details
RRB PH UT16 – Medicinal Chemistry Practice Test 1: SAR of Analgesics & Antibiotics
Premium (₹9)

View Details
RRB PH UT17 – Medicinal Chemistry Practice Test 2: SAR of Cardiovascular & Chemotherapeutic Agents
Premium (₹9)

View Details
RRB PH UT18 – Pharmacognosy Practice Test 1: Crude Drugs Classification & Evaluation
Premium (₹9)

View Details
RRB PH UT19 – Pharmacognosy Practice Test 2: Alkaloids & Phytochemical Tests
Premium (₹9)

View Details
RRB PH UT20 – Pharmacognosy Practice Test 3: Glycosides & Cardioactive Drugs
Premium (₹9)

View Details
RRB PH UT21 – Pharmacognosy Practice Test 4: Volatile Oils, Tannins, Resins & Ayurveda
Premium (₹9)

View Details
RRB PH UT22 – Pharmaceutical Jurisprudence Practice Test 1: Drugs & Cosmetics Act & Rules
Premium (₹9)

View Details
RRB PH UT23 – Pharmaceutical Jurisprudence Practice Test 2: Pharmacy Act 1948 & Allied Statutory Acts
Premium (₹9)

View Details
RRB PH UT24 – Hospital Pharmacy Practice Test 1: Organization, PTC & Drug Distribution Systems
Premium (₹9)

View Details
RRB PH UT25 – Clinical Pharmacy Practice Test: Inventory Control, Drug Interactions & TDM
Premium (₹9)

View Details
RRB PH UT26 – Biochemistry Practice Test 1: Carbohydrate, Lipid & Protein Metabolism
Premium (₹9)

View Details
RRB PH UT27 – Clinical Pathology Practice Test : Diagnostic Organ Function Tests & Urinalysis
Premium (₹9)

View Details
RRB PH UT28 – Pharmaceutical Analysis Practice Test 1: Titrations, Spectroscopy, Chromatography & GMP
Premium (₹9)

View Details
General Science Practice Test 1: CBSE Class 10 Physics
Coming 10 Nov 2026 • 12:00 PM

Coming Soon
General Science Practice Test 2: CBSE Class 10 Chemistry & Biology
Coming 10 Nov 2026 • 12:00 PM

Coming Soon
General Arithmetic Practice Test 1: Mathematics & Quantitative Aptitude
Coming 10 Nov 2026 • 12:00 PM

Coming Soon
General Intelligence & Reasoning Practice Test 1: Logical Reasoning & Current GK
Coming 10 Nov 2026 • 12:00 PM

Coming Soon
RRB Pharmacist (Entry Grade) CBT Mock Test 1
Free Test

View Details
Pharmacology Aptitude Test
Free Test

View Details
Online Practice Test for Pharmacy exams, previous Year questions
Free Test

View Details
Classification of drugs in pharmacology Aptitude Test
Premium (₹9)

View Details
Biochemistry Practice Test 1 (For Pharmacy, paramedical and other entrance exams).
Free Test

View Details
Practice test 1 (Human Anatomy and Physiology) for competitive exams
Premium (₹9)

View Details
Practice Test for Pharmacy Exams (Pharmaceutical Jurisprudence)
Free Test

View Details
Pharmaceutical Jurisprudence Practice test #2 for Pharmacy Exams
Free Test

View Details
Pharmaceutics Practice Quiz (Aptitude test for Pharmacy exams)
Free Test

View Details
Practice Test #2 Human Anatomy and Physiology
Free Test

View Details
Practice Test #1 | Pharmaceutics-II (MCQs for D.pharma)
Free Test

View Details
Practice Test #2 | Pharmaceutics-II | MCQs for Pharmacy Exams
Free Test

View Details
Practice Test #1 | Pharmaceutical Chemistry-II (organic)
Free Test

View Details
Practice Test #2 | Pharmaceutical Chemistry-II (Organic)
Free Test

View Details
HCP Practice Test #1 | Hospital and Clinical Pharmacy MCQs
Free Test

View Details
HCP Practice Test #2 | Hospital and Clinical Pharmacy MCQs
Free Test

View Details
Biochemistry MCQs based Practice test 2 | Pharmacy Exams
Free Test

View Details
Pharmacognosy Practice test #1 | MCQs for Pharmacy Exams
Free Test

View Details
Practice Test Set #1 | Pharmaceutical Chemistry 1 (inorganic) MCQs
Free Test

View Details
Pharmacology and Toxicology MCQs | Practice Test #1
Free Test

View Details
Health Education Practice Test #1 | H.E.C.P. MCQs for Pharmacy Exams
Free Test

View Details
Pharmaceutical Chemistry-1 (Inorganic) Practice Test Set #2 | P Chem 1 MCQs
Free Test

View Details
Pharmacist Exam MCQs – 50 Important Questions for Quick Revision
Free Test

View Details
RRB Pharmacist PYQ Special Mock Test: From Official PYPs
Free Test

View Details

About this Assessment

Share with Your Friends too

About This Practice Test:
This online practice test covers cardiovascular and renal pharmacology for pharmacy and paramedical exam preparation. Revise important medicines used for high blood pressure, fluid retention, heart conditions, angina and high cholesterol. The 30 questions include explanations to help you check your knowledge and revise key concepts.

Syllabus Covered:
– ACE Inhibitors and ARBs: Enalapril, captopril, losartan and aliskiren.
– Calcium Channel Blockers: Amlodipine, verapamil and important drug interactions.
– Diuretics: Furosemide, thiazides, spironolactone and amiloride.
– Cardiac Glycosides: Digoxin’s action, toxicity, electrolyte effects and specific antidote.
– Antianginal Medicines: Nitroglycerin, nitrate tolerance, nitrate-PDE5 inhibitor interaction, ivabradine and ranolazine.
– Cholesterol-Lowering Medicines: Statins, rhabdomyolysis risk and ezetimibe.
– Hypertensive Emergencies: Sodium nitroprusside and direct renin inhibition by aliskiren.

Exams You Can Prepare For:
– RRB Pharmacist and Paramedical exams
– DSSSB Pharmacist exams
– ESIC Pharmacist and healthcare recruitment exams
– AIIMS Paramedical and CGHS-related recruitment exams
– State pharmacist and paramedical recruitment tests

Test Details:
30 Questions | Online Practice Test | Explanations for Every Question | Score and Performance Review

Written & Verified by Diksha Bhatla

Expert Faculty

Diksha Bhatla is a Pharmacy graduate and a passionate academic content creator currently pursuing higher studies in Pharmacy. She contributes to SoloTutes by creating educational content, practice tests, and study resources for students preparing for NEET and Pharmacy examinations. With a strong understanding of **Biology, Chemistry, and Pharmacy**, Diksha focuses on developing clear, exam-oriented content that helps students strengthen their concepts and improve their preparation. At SoloTutes, she writes educational articles and develops practice questions and tests designed to support students in their learning and competitive exam preparation.