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One Liner

Chemical alteration of an agent (drug) that occurs by virtue of the sojourn of the agent in a biological system.

Biotransformation

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This question belongs to the set "Pharmacology Chapter 1 Revision: Key One-Liner Questions for Pharmacist Exams". Click below to read detailed notes and attempt the full quiz.

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  • A It produces less muscarinic side effects
  • B It is more potent orally
  • C It is longer acting
  • D It does not have any direct action on NM receptor
  • A Tolerance
  • B Physical dependence
  • C Psychological dependence
  • D Idiosyncrasy
  • A Undergoes little first-pass metabolism
  • B Is incompletely absorbed
  • C Is freely water soluble
  • D Is completely absorbed
  • A Highly plasma protein bound drugs
  • B Depot preparations
  • C Highly lipid soluble drugs
  • D Poorly lipid soluble drugs
  • A CYP378A
  • B CYP4B2
  • C CYP3A4
  • D CYP256
Explanation: CYP3A4 is involved in the metabolism of majority of drugs and is also expressed extrahepatically. In fact, poor bioavailability of many drugs is attributed to the drug metabolism by CYP3A4 in gastrointestinal tract.
  • A It has additional α1 blocking property
  • B It is a selective βS1 blocker
  • C It does not undergo first pass metabolism
  • D All of the above

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