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One Liner

The amount of change in measured output per unit change in input.

Amplification

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This question belongs to the set "Pharmacology Chapter 1 Revision: Key One-Liner Questions for Pharmacist Exams". Click below to read detailed notes and attempt the full quiz.

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  • A Is more painful
  • B Produces faster response
  • C Is unsuitable for depot preparations
  • D Carries greater risk of anaphylactic reaction
  • A Dapsone
  • B Meperidine
  • C Phenytoin
  • D Chlorpheniramine
Explanation: N-oxidation is involved in the metabolism of dapsone, meperidine and chloramphenicol. Metabolism of phenytoin involves oxidative Ndealkylation.
  • A Plasma protein binding
  • B Lipid solubility
  • C Degree of ionization
  • D Rate of tubular secretion
  • A Passive diffusion
  • B Facilitated diffusion
  • C Active transport
  • D Pinocytosis
  • A Nature of the base used in the formulation
  • B Lipid solubility of the drug
  • C Molecular weight of the drug
  • D Site of application
  • A CYP378A
  • B CYP4B2
  • C CYP3A4
  • D CYP256
Explanation: CYP3A4 is involved in the metabolism of majority of drugs and is also expressed extrahepatically. In fact, poor bioavailability of many drugs is attributed to the drug metabolism by CYP3A4 in gastrointestinal tract.

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