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the range of concentration of drug which produces desired response with minimal toxicity

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This question belongs to the set "Revision of Pharmacology, some basic points (one liners)". Click below to read detailed notes and attempt the full quiz.

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  • A It has additional α1 blocking property
  • B It is a selective βS1 blocker
  • C It does not undergo first pass metabolism
  • D All of the above
  • A Dapsone
  • B Meperidine
  • C Phenytoin
  • D Chlorpheniramine
Explanation: N-oxidation is involved in the metabolism of dapsone, meperidine and chloramphenicol. Metabolism of phenytoin involves oxidative Ndealkylation.
  • A Carrier is involved
  • B It is against concentration gradient
  • C Energy is required
  • D All of the above
Explanation: Facilitated diffusion differs from active transport in that it does not require energy source and it carries the transport in the direction of electrochemical gradient.
  • A Plasma protein binding
  • B Lipid solubility
  • C Degree of ionization
  • D Rate of tubular secretion
  • A CYP378A
  • B CYP4B2
  • C CYP3A4
  • D CYP256
Explanation: CYP3A4 is involved in the metabolism of majority of drugs and is also expressed extrahepatically. In fact, poor bioavailability of many drugs is attributed to the drug metabolism by CYP3A4 in gastrointestinal tract.
  • A Raynaud’s disease
  • B Infection
  • C Heart attack
  • D Epilepsy
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