What is the official composition of Simple Ointment BP/IP?

Wool fat 5%, Hard paraffin 5%, Cetostearyl alcohol 5%, Yellow or White soft paraffin 85%

Wool fat 10%, Liquid paraffin 10%, Beeswax 10%, White soft paraffin 70%

Cetostearyl alcohol 15%, Sodium lauryl sulfate 5%, Soft paraffin 80%

Hard paraffin 10%, Microcrystalline wax 10%, Wool fat 10%, Soft paraffin 70%

Which physical property fundamentally distinguishes pharmaceutical Pastes from standard Ointments?

Pastes contain a high proportion of dispersed insoluble solids (often 20% to 50%) making them stiffer and less greasy

Pastes melt rapidly at body temperature to release active ingredients into systemic circulation

Pastes are formulated exclusively with water-soluble polyethylene glycol bases

Pastes undergo syneresis when stored at refrigerated temperatures

Which synthetic hydrophilic suppository base consists of polymeric blends that dissolve in rectal mucosal secretions rather than melting at physiological body temperature?

Polyethylene Glycols (Macrogols)

What is the official ratio of Gelatin, Glycerin, and Purified Water used in preparing Glycerogelatin Suppository Base (Glycerinated Gelatin USP)?

Gelatin 20%, Glycerin 70%, Purified Water 10%

Gelatin 14%, Glycerin 70%, Purified Water 16%

Gelatin 25%, Glycerin 50%, Purified Water 25%

Gelatin 10%, Glycerin 80%, Purified Water 10%

Carbopol polymers (Carbomers) are widely utilized in pharmaceutical gel formulations as:

Synthetic cross-linked polyacrylic acid gelling agents

Polysaccharide derivatives derived from brown seaweed

Natural cellulose ether gelling agents

Inorganic clays exhibiting thixotropic swelling

Which primary chemical emulsifier is formed in situ during the preparation of classical Cold Cream (Water-in-Oil)?

Sodium cerotate (formed in situ from borax and free fatty acids in beeswax)

Vanishing creams are typically formulated as which physical type of emulsion system?

Oil-in-Water (O/W) emulsion formulated with stearic acid and an alkaline stearate soap

Water-in-Oil (W/O) emulsion containing excess lipophilic sterols

Multiple Water-in-Oil-in-Water (W/O/W) microemulsion

Non-ionic anhydrous oleaginous gel

What is the primary therapeutic rationale for incorporating 10% Salicylic Acid into an ointment vehicle?

Promoting localized keratolytic breakdown of stratified stratum corneum

Acting as an occlusive humectant

Exerting selective systemic vasoconstriction

Stimulating dermal melanin synthesis

What mechanical equipment is routinely employed in pharmaceutical manufacturing to achieve fine dispersion and eliminate grit in semisolid ointments?

Colloid Mill or Triple Roller Mill

What is the defining rheological behavior exhibited by most pharmaceutical Gels formulated with bentonite or hydrophilic polymers?

Bingham plastic flow without thinning

What is the function of Methylcellulose in dermatological gel preparations?

Non-ionic water-soluble hydrophilic gelling and thickening agent

Hydrophobic hydrocarbon solvent

Penetration enhancer that disrupts the lipid bilayer

Which fatty suppository base consists of hydrogenated triglycerides of lauric acid derived from palm kernel oil, with a negligible post-heating crystallization hysteresis?

Semi-synthetic Hard Fats (Witepsol / Suppocire)

Which option gives a commonly cited composition of Zinc Gelatin (Unna's Paste) used in dermatological dressings?

Zinc oxide 15%, Gelatin 15%, Glycerin 35%, Purified water 35%

Zinc oxide 5%, Gelatin 40%, Glycerin 45%, Purified water 10%

Zinc oxide 40%, Gelatin 10%, Glycerin 10%, Purified water 40%

Zinc oxide 25%, Gelatin 25%, Glycerin 25%, Purified water 25%

Which of the following describes an Oleaginous ointment base according to the USP classification?

Anhydrous, hydrophobic base that is immiscible with water and cannot absorb meaningful moisture

Hydrophilic anhydrous base that absorbs water to yield an O/W emulsion

Water-washable emulsion containing sodium lauryl sulfate

Polyoxyethylene polymer base that dissolves completely in water

In the compounding of suppositories, why is it necessary to 'calibrate' the mold cavities before regular production?

Because mold volume capacity varies depending on manufacturing tolerances and the specific gravity of the base used

Because molds expand in thermal ovens during routine sterilization

To verify that the metal alloy contains exactly 70% nickel

To ensure that the suppository active ingredient does not undergo base-catalyzed hydrolysis

What is the consequence of adding an excessive amount of electrolyte to an aqueous carbomer (Carbopol) gel?

Drastic loss of viscosity and breakdown of the polymeric gel structure

Instantaneous conversion into a stiff irreversible paste

Formation of an immiscible oily phase

Oxidation of carboxylate moieties into free radical peroxides

Which testing method is commonly used to assess the consistency of semisolids such as ointments and petrolatum?

Brookfield concentric cup testing

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RRB PH UT06 – Pharmaceutics Practice Test 2: Semisolid Dosage Forms

Diksha Bhatla November 6, 2026 11 views 30 Questions

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About This Practice Test
This online practice test covers semisolid dosage forms and suppositories in Pharmaceutics. Topics include ointment-base classifications, paste consistency, carbomer gel formation, cocoa-butter polymorphism, and suppository displacement-value calculations. Use it to revise core pharmaceutics concepts for pharmacy and paramedical examinations. Confirm the applicable syllabus and pharmacopoeial standards for your target examination.

Syllabus Covered
• Ointment bases: oleaginous, absorption, water-removable and water-soluble bases; Simple Ointment composition
• Suppository bases and excipients: cocoa-butter polymorphism, PEG/Macrogols and glycerinated gelatin
• Displacement-value calculations and mold calibration
• Pastes and gels: high-solid formulations, carbomer neutralization, syneresis and thixotropy
• Creams and topical formulations: cold cream, vanishing cream, penetration enhancers and semisolid consistency testing

Applicable Examinations
Potentially relevant to pharmacy and paramedical recruitment preparation, including RRB Pharmacist, DSSSB Pharmacist, ESIC and state-level pharmacist examinations. Candidates should check the latest official notification and syllabus for each examination before relying on this test for coverage.

Test Instructions & Features
30 Questions | Timed Online Test | Explanations | Scorecard and Performance Analysis (where supported by the SoloTutes platform) | Test code : RRB PH UT06

Written & Verified by Diksha Bhatla

Expert Faculty

Diksha Bhatla is a Pharmacy graduate and a passionate academic content creator currently pursuing higher studies in Pharmacy. She contributes to SoloTutes by creating educational content, practice tests, and study resources for students preparing for NEET and Pharmacy examinations. With a strong understanding of **Biology, Chemistry, and Pharmacy**, Diksha focuses on developing clear, exam-oriented content that helps students strengthen their concepts and improve their preparation. At SoloTutes, she writes educational articles and develops practice questions and tests designed to support students in their learning and competitive exam preparation.