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Enteral routes of drug administration

Oral, sublingual and rectal routes
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  • A CYP378A
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Explanation: CYP3A4 is involved in the metabolism of majority of drugs and is also expressed extrahepatically. In fact, poor bioavailability of many drugs is attributed to the drug metabolism by CYP3A4 in gastrointestinal tract.
  • A Highly plasma protein bound drugs
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  • A Albumin
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Explanation: Glycoprotein binds to basic drugs and albumin binds to many acidic drugs and a small number of basic drugs.
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