Thevetin A
Medicinal Chemistry
Molecular Weight
872.95
Molecular Formula
C42H64O19
IUPAC Name
3-[(O-beta-D-glucopyranosyl-(1->4)-O-beta-D-glucopyranosyl-(1->4)-6-deoxy-3-O-methyl-alpha-L-glucopyranosyl)oxy]-14-hydroxy-19-oxocard-20(22)-enolide
Pharmacognosy
Biological Source
Thevetia peruviana (Yellow Oleander)
Active Constituents
Thevetin A, Thevetin B
Pharmacology & Synthesis
Mechanism of Action
Potent inhibitor of the Na+/K+-ATPase pump in the myocardium.
Pharmacokinetics (ADME)
A: Rapidly absorbed.
D: High myocardial affinity.
M: Hepatic.
E: Renal.
Pharmacodynamics
Positive inotropy; extremely narrow therapeutic index, mostly encountered in toxicology.
Synthesis Pathway
Biosynthesized from steroidal precursors.
Safety, Warnings & Interactions
Adverse Effects
Severe cardiac arrhythmias, vomiting, hyperkalemia.
Contraindications
Highly toxic; not used clinically.
Drug Interactions
Diuretics (toxicity exacerbated by hypokalemia).