Sennoside B
Medicinal Chemistry
Molecular Weight
862.74
Molecular Formula
C42H38O20
IUPAC Name
(9R,9'S)-5,5'-bis(beta-D-glucopyranosyloxy)-4,4'-dihydroxy-10,10'-dioxo-9,9'-bianthracene-2,2'-dicarboxylic acid
Pharmacognosy
Biological Source
Cassia acutifolia, Cassia angustifolia
Active Constituents
Sennosides A, B
Pharmacology & Synthesis
Mechanism of Action
Stereoisomer of Sennoside A; metabolized by gut flora to rhein-anthrone, stimulating myenteric plexus.
Pharmacokinetics (ADME)
A: Negligible in upper GI.
D: Colonic.
M: Bacterial cleavage in colon.
E: Fecal and renal.
Pharmacodynamics
Increases colonic peristalsis, increases water in intestinal lumen.
Synthesis Pathway
Dimeric structure derived from the polyketide pathway.
Safety, Warnings & Interactions
Adverse Effects
Abdominal cramping, electrolyte imbalance, red-colored urine.
Contraindications
Intestinal obstruction, ulcerative colitis.
Drug Interactions
Diuretics, digoxin.
Pharmaceutics & Compendia
Dosage Forms
Tablets, Syrups
Official Compendia
IP, BP, USP