Rutin
Medicinal Chemistry
Molecular Weight
610.52
Molecular Formula
C27H30O16
IUPAC Name
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranosyloxy]-4H-chromen-4-one
Pharmacognosy
Biological Source
Ruta graveolens, Sophora japonica, Fagopyrum esculentum (Buckwheat)
Active Constituents
Rutin
Pharmacology & Synthesis
Mechanism of Action
Antioxidant; inhibits platelet aggregation, decreases capillary permeability.
Pharmacokinetics (ADME)
A: Poorly absorbed intact; hydrolyzed to quercetin.
D: Widely distributed.
M: Intestinal microbiota and hepatic.
E: Renal and fecal.
Pharmacodynamics
Strengthens capillaries, reduces edema, antioxidant.
Synthesis Pathway
Biosynthesized via the shikimate and polyketide pathways.
Safety, Warnings & Interactions
Adverse Effects
Headache, flushing, mild GI upset.
Contraindications
None strictly known.
Drug Interactions
May affect metabolism of CYP3A4 substrates.
Pharmaceutics & Compendia
Dosage Forms
Capsules, Tablets
Official Compendia
BP